Clinical Studies of the Ingredient of Advaslim Below are some select clinical studies on chitosan: Chitosan decreases total cholesterol in women: a randomized, double-blind, placebo-controlled trial Bokura H, Kobayashi, S Eur J Clin Nutr. 2003 May;57(5):721-5.     Cholesterol-lowering properties and safety of chitosan Ylitalo R, Lehtinen S, Wuolijoki E, Ylitalo P, Lehtimaki T Arzneimittelforschung. 2002;52(1):1-7. Review.     Clinical and biochemical evaluation of chitosan for hypercholesterolemia and overweight control Muzzarelli RA EXS. 1999;87:293-304. Review.     Effect of Chitosan on Plasma Lipoprotein Concentrations in Type 2 Diabetic Subjects with Hypercholesterolemia Tai TS Diabetes Care. 2000; Nov.     Mechanism for the inhibition of fat digestion by chitosan and for the synergistic effect of ascorbate Kanauchi O, Deuchi K, Imasato Y, Shizukuishi M, Kobayashi E Biosci Biotechnol Biochem 1995;59:786-790     Effect of orlistat and chitosan on fecal fat excretion in young healthy volunteers Lengsfeld H, Fleury A, Nolte M, Piquerez JC, Hadvary P, Beglinger C Obes Res 7 (Suppl. 1) 1999; 50S     Decreasing effect of chitosan on the apparent fat digestibility by rats fed on a high fat diet Deuchi K, Kanauchi O, Imasato Y, Kobayashi E Biosci Biotech Biochem 1994;58:1613-6 Below are some select clinical studies on calcium pyruvate: Body composition, energy utilization, and nitrogen metabolism with a 4.25-MJ/d low diet energy supplemented with pyruvate Stanko RT, Tietze DL, Arch JE Am J Clin Nutr 1992; 56:630-5     Body composition, energy utilization, and nitrogen metabolism with a severely restricted diet supplemented with dihydroxyacetone and pyruvate Stanko RT, Tietze DL, Arch JE Am J Clin Nutr 1992; 55:771-5     Inhibition of lipid accumulation and enhancement of energy expenditure of the addition of pyruvate and dihydroxyacetone to a rat diet Stanko RT, Adibi SA Metabolism 1986; 35:182-6     Effects of pyruvate and dihydroxyacetone consumption on the growth and metabolic state of obese Zuker rats Cortez MY, Torgan CE, Brozinick JT, Miller RH, Ivy JL Am J Clin Nutr 1991;53:847-53     The binding of micellar lipids of chitosan Nauss JL, Thompson L, Nagyvary J Lipids 1983;18:714-9 Below are some select clinical studies on Commiphora mukul (guggulipid): Gugulipid: A natural cholesterol-lowering agent Urizar NL, Moore DD. Annu Rev Nutr. 2003 Feb 26     A natural product that lowers cholesterol as an antagonist ligand for FXR Urizar NL, Liverman AB, Dodds DT, Silva FV, Ordentlich P, Yan Y, Gonzalez FJ, Heyman RA, Mangelsdorf DJ, Moore DD. Science. 2002 May 31;296(5573):1703-6.     Long-term clinical studies on the hypolipidemic effect of Commiphora mukul (guggul) and clofibrate Malhotra SC, Ahuja MMS, Sundarum KR. Ind J Med Res 1977;65:390–5.     Hypocholesterolemic effect of Commiphora mukul resin (Guggal) Nityanand S, Kapoor NK. Indian J Exp Biol 1971;9:367–77.     Hypolipidemic and antioxidant effects of Commiphora mukul as an adjunct to dietary therapy in patients with hypercholesterolemia Singh RB, Niaz MA, Ghosh S. Cardiovasc Drugs Ther. 1994 Aug;8(4):659-64.

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